From Hair Regrowth to Skin Renewal: Japan's Pioneering Advances in Exosome Therapy
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Imagine reversing the clock on aging or halting the distressing advance of hair loss. A breakthrough is on the horizon in Japan that promises just that.
Exosome therapy, a state-of-the-art therapy, is garnering attention for its potential to rejuvenate skin and restore hair. This isn’t just a fleeting trend but a scientific innovation rooted in cellular biology that could offer lasting solutions to these pervasive concerns.
In this article, I will introduce the basics of exosome treatment, a beacon of hope for those seeking to renew their youthful vitality and regain full, healthy hair.
*Please note that this article contains affiliate links.
*Note: Before I start explaining, let me remind you that we aren’t experts in this field, and the information we provide in this article is all general info.
If you’re interested in taking this treatment and want to know more about the details, we suggest that you make an appointment at one of these clinics and ask the specialist.
What is Exosome Therapy?
What are exosomes?
Exosomes are microscopic messengers, carrying vital information between cells.
Discovered in the 1980s, these vesicles were initially thought to be cellular waste. Yet, it soon became clear they held the keys to intercellular communication, brimming with proteins, RNA, and other molecules. These natural nanoparticles are now at the forefront of medical research, heralding a new wave of treatments that harness the body’s intrinsic healing mechanisms.
What is Exosome Therapy?
Exosome therapy has roots in regenerative medicine, evolving rapidly over the past few decades.
The therapy involves isolating exosomes, particularly those rich in growth factors like umbilical cord exosomes, which are believed to be the most potent. In Japan, renowned for its precision and technological advancement, exosome production has reached exceptional standards of quality. These exosomes are then used in various fields, including beauty care, where they’re applied topically or injected to rejuvenate skin and scalp.
Medical applications are diverse, from promoting wound healing to potentially treating chronic diseases. While there are different methods of administering exosome therapy, the focus remains on utilizing the highest quality exosomes, with Japan’s umbilical cord exosomes leading the way.
What are high-quality exosomes?
The quality of exosomes is defined by the quality of the cells it derives from. There are two main factors that define the quality of cells used for exosome therapy. These two factors are the following.
1. Cells with little DNA damage
2. Cells that are young.
The primary cause of DNA damage is exposure to ultraviolet rays. Since the umbilical cord is in a state where it is not exposed to ultraviolet rays within the mother’s body, umbilical cord cells have little to no damage as you can see from the image above (WJ-MSC).
*The risk of using cells with a high level of DNA damage results in a culture supernatant that contains more harmful exosomes, which accelerate aging, and a greater amount of inflammatory cytokines.
Therefore, as I previously mentioned, umbilical cord exosomes are regarded as the highest-quality exosomes due to having the least DNA damage and being the cells collected at the youngest stage.
Benefits of Exosome Therapy
The benefits of exosome therapy, particularly in the realms of anti-aging and hair loss, are substantial.
For anti-aging, exosome treatments aim to rejuvenate the skin by promoting cell renewal and collagen production, which can improve skin texture, reduce wrinkles, and restore a youthful complexion. The growth factors and proteins in exosomes can signal skin cells to repair and regenerate, which can help in slowing down the aging process.
When it comes to hair loss, exosome treatment is believed to stimulate hair follicles, potentially leading to hair regrowth. It may work by delivering growth signals to hair follicle cells, encouraging them to remain in the growth phase and preventing hair thinning and baldness.
As with any treatment, there are risks and potential downsides, such as immune reactions or unanticipated effects, but these are generally minimal. If you have any concerns about the treatment, it is good that you ask the specialist beforehand.
Popular clinics in Japan that offer treatment using high-quality supernatant treatments
In Japan, clinics offering high-quality supernatant treatments are distinguished by several key characteristics.
Foremost among these is the utilization of umbilical cord-derived cells which are recognized for being the most effective and scarce cells for producing exosomes.
In the case of the clinics that we’re about to introduce in this article, these treatments are entirely made in Japan, a testament to their authenticity and quality, and are developed in a leading regenerative medicine laboratory based in Kyoto. This underscores Japan’s commitment to innovation in medical technology.
Furthermore, these clinics adhere to rigorous manufacturing processes and safety inspections, ensuring the highest quality of their products and treatments. This attention to detail and quality underlines the clinics’ dedication to providing superior healthcare solutions.
1. Ginza Nana Clinic (Tokyo)
Ginza Nana Clinic (医療法人さくら会銀座NANAクリニック), located immediately off the Ginza Station on the Ginza Line in Tokyo, is a beauty clinic that offers a wide range of treatments. Services include AGA treatment for hair growth, slimming treatment, medical hair removal, skin improvement treatments, anti-aging injections, and regenerative medicine among others.
When it comes to stem cell culture supernatant treatments, patients can choose from dental pulp, bone marrow-derived mesenchymal, umbilical cord blood, adipose stem cells, and exosome therapies. The clinic prides itself on evidence-based state-of-the-art medical technology, empathetic counseling, and optimal support tailored to the lifestyles of its clients.
Here are some reviews from patients.
- The customer service and response were really good, and the effects of the stem cells also seemed promising.
- This time, I received stem cell IV drips and injections. I was guided very politely through everything and was able to receive treatment with peace of mind. I would like to continue visiting.
- I was administered a blend of umbilical and dental pulp stem cells, and I noticed improvements in my vision, fatigue recovery, and even my skin wrinkles are gone. Being able to obtain beauty and health with regular treatments is truly a joy.
 Access |
6 minute walk from Ginza Station (Tokyo Metro) |
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 Official Website |
https://ginza-nana-clinic.or.jp/ |
2. Setagaya Internal Medicine/Diabetes Comprehensive Clinic (Tokyo)
The clinic offers specialized anti-aging consultations conducted by expert physicians. For stem cell culture supernatant treatments, patients can choose from human stem cell exosome-containing culture supernatant IV therapy, umbilical cord-derived stem cell and Wharton’s Jelly IV drips, dental pulp and adipose-derived stem cell exosomes, and stem cell exosome nasal therapy.
Here are some reviews from patients.
- Everyone, from the receptionist to the nurses, feels like an angel with a genuinely good nature, not just a mechanical niceness, but a kindness that seems to come from within. It makes visiting the clinic a very pleasant experience.
- I have been receiving beauty IV treatments. The receptionists and nurses are so kind and always make me feel at ease.
- I have been receiving IV treatments and consultations, and I find it easy to talk to a doctor who responds with empathy and care, which I greatly trust. I’m happy to have found such a good clinic.
| Access |
3 minute walk from Okusawa Station (Meguro Line), 7 minute walk from Jiyugaoka Station (Toyoko Line) |
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| Official Website |
https://www.setagaya-dm.clinic/ |
3. M Clinic (Tokyo)
M Clinic (Mクリニック), a dermatology clinic in Shibuya, specializes in customized beauty treatments for each individual.
Offering a broad spectrum of services, it addresses skin issues like spots, sagging, mole and wart removal, and a variety of advanced cosmetic procedures like chemical peels, Pico lasers, and Dermapen 4. The clinic also provides treatments like CO2 laser, Photo IPL Facial, high-frequency RF, and a wide range of IV therapies and injections for skin and overall wellness.
Notably, for exosome therapy (umbilical cord blood-derived stem cell culture supernatant), patients can choose from 1ml, 2ml, or 3ml options, showcasing its commitment to cutting-edge beauty treatments in Japan.
Here are some reviews from patients.
- The clinic is easily accessible, very clean, and above all, the staff are kind.
- It was my first visit, and I was impressed by how clean and uplifting the clinic was. The director was a really good and wonderful doctor. I went with a friend and arrived early. While waiting for my friend in the waiting room, they even served me tea and were incredibly kind.
- It was my first time receiving cosmetic medical treatment, but I was greatly comforted not only by the director but also by the assistant’s response and the lovely interior. I hope to consult them about other skin concerns in the future.
| Access |
3 minute walk from Shibuya Station (Tokyo Metro Fukutoshin Line Exit B1) |
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| Official Website |
https://mclinic-shibuya.com/ |
4. Kirei Clinic (Kyoto)
Kirei Clinic (きれいクリニック) in Kyoto embodies the concept of “Bringing cosmetic medicine closer to you.” A standout feature of Kirei Clinic is its thorough and easy-to-understand counseling.
The clinic offers a diverse range of treatments, including human stem cell culture supernatant, NMN IV drips, beauty IV drips, spot-removing Pico lasers, thread lifts, Super Phototherapy, Botox, Dermapen, ZO SKIN, and chemical peels among many other aesthetic treatments.
For stem cell and high exosome IV drips, options include umbilical cord-derived, adipose-derived, and dental pulp-derived exosomes, highlighting its dedication to cutting-edge beauty treatments in Japan.
Here are some reviews from patients.
- During the counseling, they first thoroughly listened to my previous treatment dissatisfaction and what I’m currently struggling with. Then, the doctor explained several recommended treatments for my symptoms, detailing the merits and demerits of each, as well as the budget. The doctor was easy to talk to and provided clear explanations.
- I had seen regenerative medicine on TV, so I decided to try a stem cell IV drip. After three weeks, my skin started to feel firmer and after a month, my spots also began to fade. My daughter even told me I looked more beautiful, which made me happy.
| Access |
3 minute walk from Karasuma Station (Hankyu-Kyoto Line) |
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| Official Website |
https://www.kirei-clinic.com/ |
5. Jakuchuan Beauty Clinic (Kyoto)
Jakuchuan Beauty Clinic (若冲庵クリニック) in Kyoto is a must-visit destination for those seeking a luxurious, ryokan-style beauty clinic experience. Set in an extraordinary space, the clinic offers exceptional hospitality.
Catering to a wide array of cosmetic surgery and dermatological needs, this clinic provides treatments like regenerative medicine, hyaluronic acid, Botox, Water Light Injection, Pico laser, and treatments for spots, melasma, moles, and acne.
In the realm of regenerative medicine, the clinic not only offers adipose-derived stem cell therapy but also PRP (Platelet-Rich Plasma) and VFD (Vampire Facelift) treatments, positioning itself at the forefront of advanced beauty treatments.
Here are some reviews from patients.
- It was a very beautiful clinic with a calm atmosphere. I felt reassured during the procedure as they kept talking to me and made sure I was comfortable.
- The counselor, nurses, and the doctor were all wonderful people, and extremely knowledgeable, making it an excellent clinic. I will definitely return for more services.
- In a setting that makes you forget everyday life, there was warm hospitality from the doctor and all the staff. Although I was nervous about my first treatment, I had a great time. Thank you very much.
| Access |
3 minute walk from JR-Fujinomori Station (Nara Line) |
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| Official Website |
https://jakuchu-an-biyo-clinic.com/ |
I hope this article was helpful. Exosome Therapy stands at the cutting edge of beauty and medical therapies in Japan, offering a transformative approach to health and wellness. With continued research and development, this innovative treatment may soon become a cornerstone in our quest to heal and rejuvenate the human body.
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Written by
Born and raised in Costa Rica, I started living in Tokyo from college. I love traveling within Japan & around the world. Since I wasn’t born in Japan, I know the cultural impact that you can get when visiting Japan for the first time and what you might be worried about before your trip. And I’ve lived long enough to somewhat understand the nuances of the Japanese culture that make this country such an attractive place to visit. Hopefully I can provide to you both the information you’re looking for and the information you didn’t know you needed to know.
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